Frontiers of Biomedical Engineering (BENG 100) Professor Saltzman discusses the biophysics of the circulatory system. He begins by describing the anatomy of different types of blood vessels, and notes the relationship between the pressure difference (AP) as the driving force for fluid flow (Q) in a tube (blood vessel), with some resistance R (AP = RQ). R can be calculated when the pipe size (L, R) and viscosity (μ) are known: R = 8μL/πr4. Subsequently, Professor Saltzman tracesthe flow of blood through the circulatory system and explains how the body can regulate blood flow to certain areas of the body. Finally, it describes the heart and its function as a generator of pressure in the system. comprehensive training material on the site are Open Yale Courses Web: open.yale.edu This course has been taken in the spring of 2008.
Frontiers of Biomedical Engineering (BENG 100) Professor Saltzman talks about electrical conductivity in the heart: that is, the generation and propagation of electrical potential in heart cells. He describes the role of ion channels and pumps in transporting sodium, potassium, and calcium ions to create action potential. This propagation of signal from the sinoatrial node through different tissues, which can be replaced by a pacemaker, eventually stimulates contraction of muscle fibers throughout the heart. Next, he describes the electrocardiograph and how each wave trace corresponds to the events caused by depolarization/repolarization of different heart tissues. Complete course materials are available at the Open Yale Courses website: open.yale.edu This course was recorded in Spring 2008.